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Bendesky, Andres

E3B Assistant Professor & Zuckerman Mind Brain Behavior Institute Investigator

Assistant Professor
M.D. -- Universidad Nacional Autónoma de México: Ph.D. -- Rockefeller University
Research Description

There are profound differences in behavior among individuals of a species and across species. Much effort has been devoted to the observation and theory of behavioral variation, but the molecular, genetic, and neurobiological mechanisms that generate and maintain such diversity are largely unknown. My lab studies the mechanisms of behavioral variation from genetic and neurobiological angles – by identifying specific genes involved and how they impact the brain, and by characterizing functional variation in neuronal circuits. We then analyze the common themes that emerge to describe the evolution of behavior.

Research Keywords: Genetics; Quantitative Genetics; Genomics; Natural variation; Evolution; Animal & Social Behavior; Sociobiology; Neurobiology; Peromyscus; Deer mice

Representative Publications

Bendesky A, Kwon, YM, Lassance JM, Lewarch CL, Yao S, Peterson BK, He MX, Dulac C, Hoekstra HE. The genetic basis of parental care evolution in monogamous mice. Nature. 2017;544:434-439.
News and Views:
Phelps SM. Animal behaviour: How to build a better dad. Nature. 2017;544:418–419.
Hager R. The genes that make a good parent. Trends in Genetics. 2017; In press.
Matheson S. Sorting out complex thoughts and messy emotions. Cell. 2017;169:1157.
Media coverage:
Carl Zimmer. Why are some mice (and people) monogamous? A study points to genes. New York Times. April 19, 2017.
Andrea Marks. The mouse parent trap. Scientific American. July 2017.

Bendesky A, Pitts J, Rockman MV, Chen WC, Tan MW, Kruglyak L, Bargmann CI. Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus (QTL) for social behavior in Caenorhabditis elegans. PLoS Genet. 2012;8:e1003157.

Bendesky A, Bargmann CI. Genetic contributions to behavioural variation at the gene-environment interface. Nature Reviews Genetics. 2011.;12:48-56.

Bendesky A, Tsunozaki M, Rockman MV, Kruglyak L, and Bargmann CI. Catecholamine receptor polymorphisms affect decision-making in C. elegans. Nature. 2011;472:313-318.

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